PTEN, energy metabolism and tumor suppression
نویسندگان
چکیده
منابع مشابه
Tenets of PTEN Tumor Suppression
Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23 locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor types. A decade of work has established that PTEN is a nonredundant phosphatase that is essential for regulating the highly oncogenic prosurvival PI3K/AKT signaling pathway. This review discusses emerging modes of PTE...
متن کاملUbiquitination Regulates PTEN Nuclear Import and Tumor Suppression
The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN mutation causes cancer-susceptibility conditions such as Cowden syndrome. PTEN acts as a plasma-membrane lipid-phosphatase antagonizing the phosphoinositide 3-kinase/AKT cell survival pathway. However, PTEN is also found in cell nuclei, but mechanism, function, and relevance of nuclear localization remain uncle...
متن کاملPTEN level in tumor suppression: how much is too little?
The importance of PTEN (phosphatase and tensin homolog located on chromosome 10) in cancer has surpassed all predictions and expectations from the time it was discovered and has qualified this gene as one of the most commonly mutated and deleted tumor suppressors in human cancer. PTEN levels are frequently found downregulated in cancer, even in the absence of genetic loss or mutation. PTEN is h...
متن کاملEndogenous tumor suppression mediated by PTEN involves survivin gene silencing.
Endogenous tumor suppression provides a barrier against oncogenesis, but the molecular requirements of this process are not well understood. Here, we show that the dual specificity phosphatase PTEN, a gene almost universally altered in human tumors, silences the expression of survivin, an essential regulator of cell division and apoptosis in cancer. This pathway is independent of p53, involves ...
متن کاملThe Multiple Roles of PTEN in Tumor Suppression
missense mutations in PTEN detected in primary tumors and in cell lines are confined to exon 5, which encodes this domain. Despite its homology with dual-specificity phosphatases, PTEN is an inefficient protein phospha-tase in vitro; however, it is very active on highly acidic Sloan-Kettering Institute New York, New York 10021 substrates. This finding suggested that the substrates of PTEN might...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2012
ISSN: 1672-9145,1745-7270
DOI: 10.1093/abbs/gms048